Heavy proteinuria usually indicates glomerular disease.

The glomerulus is the proximal part of the nephron and is the main filtration unit in the kidney. It is made up of three principle layers listed in order of proximity to blood:

Fenestrated endothelium

Basement membrane

Podocytes (contain foot processes)

The glomerular basement membrane is negatively charged and repels most negative... more

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Michael Miller
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